\documentclass{xetex-letter}
\setmainfont[Numbers=OldStyle]{Minion Pro}
\def \first {Isac}
\def \last {Asimov}
\def \street {Random St. 21}
\def \city {9873 New York}
\def \recipientHighlight {Human Resources}
\def \recipientRest {Some Company Ltd. \\ Some Street 123 \\ 12345 Some City}
\usepackage{lipsum}
\usepackage{polyglossia}
\setmainlanguage{english}
\begin{document}
\foldingmarks
\letterstart
\salutation{Dear Sir or Madam,}
\lipsum[1-2]
\closing{Sincerely yours,}
\enclosure[Attached]{curriculum vit\ae{}}
\letterend
\end{document}