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import re
s = 'lljdfjlajsdffoo*lkajdsfl?ajsdf'
%timeit re.search('[\?\*]', s)
%timeit '?' in s or '*' in s
625 loops, best of 3: 1.19 µs per loop 625 loops, best of 3: 70.6 ns per loop 
import re
s = 'lljdfjlajsdffoolkajdsflajsdf'
%timeit re.search('[\?\*]', s)
%timeit '?' in s or '*' in s
625 loops, best of 3: 1.16 µs per loop 625 loops, best of 3: 126 ns per loop